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  • br review editing Catriona R

    2020-08-18


    - review & editing. Catriona R. Mayland: Writing - original draft, Writing - review & editing, Supervision. Stephen Mason: Writing - review & editing, Supervision. Andrea Varro: Supervision. John Eller-shaw: Supervision.
    Acknowledgements
    We thank Professor Antonio Piccoli ([email protected]) for the free use software to analyse the RXc graphs and vector BIA analysis. Amara Nwosu and Sarah Stanley's hospice posts are supported by Marie Curie. Amara Nwosu and Sarah Stanley's academic posts are supported by the National Institute for Health Research (NIHR) North West Coast - Clinical Research Network (CRN).
    List of abbreviations used
    BIA bioelectrical impedance analysis
    BIVA bioelectrical impedance vector analysis
    CAH clinical assisted hydration
    ECOG Eastern Cooperative Oncology Group performance
    status
    M mean
    R resistance - Ohm
    R/H resistance normalized by the height - m
    Xc reactance - Ohm
    Xc/H reactance normalized by height
    RXc resistance/reactance
    TBW total body water
    FFM fat free mass
    FM fat mass
    PA phase angle - degrees
    ESPEN European Society for Clinical Nutrition and Metabolism
    BMI Body Mass Index - height/weight2 [kg/m2]
    Appendix
    Formulas for the calculation of the bio-impedance confi-dence and tolerance ellipses.
    The following section has been adapted (with permission) from Piccoli A, Pastori: BIVA software [25].
    Geometrical parameters for drawing the RXc Graph and the RXc-score Graph.
    Confidence and tolerance intervals can be calculated for the bivariate normal distribution [46e50]. A simple linear correlation analysis can be used for calculation following appropriate modifi-cation of the equations [9,23].
    Given n pairs of observations x and y, with standard deviation sx and sy, and correlation coefficient r, for a fixed a probability level, the Snedecor's Fa value CHIR 265 taken with 2 and n-2 degrees of freedom. RXc Graph.
    RXc-score graph.
    The parameters of tolerance ellipses of bivariate Z-scores (RXc Zscore graph) can be calculated accordingly, using equations 1b and 2b [23].
    L1; L2 ¼ sffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiðÞþðÞþðÞ
    ffiffiffiffi
    rffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
    x y h
    x
    y i
    x
    y
    Equation 1 b
    where
    ¼ sy2 sx2 rffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
    Equation 2b
    References
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